Tabriz University of Medical Sciences ImmunoAnalysis 2783-2589 2 1 2022 01 29 An Overview on Electrochemical Approaches for the Detection of Alpha-Fetoprotein 4 4 10.34172/ia.2022.04 EN Zahra Golsanamlu https://orcid.org/0000-0002-3044-3086 Jafar Soleymani https://orcid.org/0000-0002-8316-5104 Journal Article 10.34172/ia.2022.04 2022 11 09 2022 11 29 Cancer biomarkers have a remarkable role for not only early-stage detection of cancer but also in the monitoring therapy efficacy. Alpha-fetoprotein (AFP) is one of the biomarkers which is highly expressed in hepatocellular carcinoma (HCC) patients. Therefore, a high level of AFP can be considered for early diagnosis of HCC. Electrochemical assays can be used as the miniaturized biosensors for real-time detection of the analytes which are mostly categorized into three groups for AFP detection including immunosensors, aptasensors, and molecularly imprinted polymer-based sensors. All of these techniques provide beneficial detection features of fast and cost-effective compared with other analytical methods. This review describes the most recent electrochemical platforms for AFP detection to provide a perspective for future studies.