Tabriz University of Medical Sciences ImmunoAnalysis 2783-2589 4 1 2024 01 20 Novel Approaches Used for Decreasing Apoptosis Rate in Ovarian Tissue Cryopreservation and Transplantation 2 2 10.34172/ia.4055 EN Mahsa Rezaei Zarnaghi https://orcid.org/0000-0003-3468-6162 Zahra Bahroudi Melika Izadpanah https://orcid.org/0000-0003-1227-6875 Abbas Majdi Seghinsara Ali Abedelahi https://orcid.org/0000-0002-9489-8178 Journal Article 10.34172/ia.4055 2023 06 02 2024 02 17 Apoptosis is the main cause of atresia in ovarian follicles. In oxidative stress (OS) conditions, an imbalance between pro-apoptotic and anti-apoptotic genes can increase the apoptosis rate. In some diseases, such as cancers, patients lose fertility due to chemotherapy and radiotherapy. One way to maintain fertility in these patients is ovarian tissue cryopreservation and transplantation (OTC/T). Studies show that OTC/T also increases apoptosis due to hypoxia and ischemia but fortunately new findings show that applying new approaches could decrease apoptosis in these procedures considerably. This article reviewed follicular atresia, apoptosis during cryopreservation and transplantation, and factors affecting the reduction of apoptosis.