Revealing Facts About CAR-T Cell Therapy

Abstract

Chimeric antigen receptor (CAR)-T cell therapy is a fast-emerging treatment for several types of cancers and has several applications beyond oncology. It is a new emerging treatment targeting for a broad range of cancers. The objective of this review is to provide the trending information on CAR-T cell therapies, basic principles involved in the CAR-T cell therapy, structure of CAR-T cell, and mainly various clinical applications in the field of oncology as well as beyond oncology, and major side effects of CAR-T cell therapy, methods to overcome the risk factors and to minimize the cost. Although, the cost of treatment is enormous, cost effectiveness can be done by understanding the demand informed by tertiary healthcare centers to manufacture units for decreasing the complexity of the procedure. But this therapy is associated with few-toxicities. Monitoring these toxicities and minimizing the severity is the main future prospective of CAR-T cell therapy. The next stage in developing CAR-T cell therapy for malignancies is to limit exposure to specific cells because future CAR-T cells can target different antigens. Due to the increasing number of potential targets for CAR-T cell therapy, this approach’s tremendous success in treating cancer may also be used to the treatment of other diseases.

Keywords: CAR-T cell therapy, Cancer, Cytokine release syndrome, Immunotherapy, Tocilizumab